Combinatorial Targeting of Oncogene-Driven Childhood Cancer - Stand Up To Cancer

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SU2C-CRUK Pediatric Cancer New Discoveries Challenge: Combinatorial Targeting of Oncogene-Driven Childhood Cancer

Grant Term: 2 Years

The SU2C-CRUK Pediatric Cancer New Discoveries Challenge is a new, focused effort to spark novel approaches and new collaborations from investigators both within and outside the field of paediatric cancer research, with the ultimate aim of increasing the number of innovative and effective approaches to treating paediatric cancers. This program will support collaborative, multi-disciplinary, multi-institutional, trans-Atlantic Teams to pursue a transformative change in our understanding of the drivers of paediatric cancers and the development of novel or repurposed medicines, treatment strategies or technologies. With a clear and rational line of sight to the clinic,these projects will have the potential to significantly impact paediatric cancer patients, including teenagers and young adults.

ABOUT THIS TEAM’S RESEARCH

A major issue in the field of paediatric cancer is the plateauing of survival rates due to cancers that are inherently resistant to conventional frontline therapies. While there is much optimism due to the success of immunotherapies in the treatment of cancers, the application of these same agents to childhood cancers has been a disappointment. The diminished efficacy in children could be due to either immune evasion by paediatric tumours or an increased ability to create a barrier to immune cells. The Team proposes to address these possibilities in both neuroblastoma and medulloblastoma by: 1) designing CAR-T cells to overcome immune evasion as well as overcoming immune barriers by both formulating new compounds to overcome tumour growth and immune barrier formation and 2) by using a combination of drugs called an “in situ vaccine” to strengthen immune responses. They also propose to test combinations promising options arising from both aims to increase therapeutic efficiency.

 

Pediatric New Therapies Challenge Overview

MEET THE TEAM

This is a collaborative, multi-disciplinary, multi-institutional, trans-Atlantic Teams Research Team that includes expertise beyond paediatric oncology (e.g. other areas of oncology, biology, chemistry, engineering, physics, etc.) and investigating one or more of the following concepts: the basis of tumour initiation and progression; novel therapeutic approaches; development of novel biomarkers or methodologies to predict disease progression, to enhance efforts in primary and secondary prevention and intervention; novel models that would enhance pre-clinical research; development of more effective and/or less toxic treatments to improve long-term health and quality of life.

Research Team Members

Team Leader
John Anderson, BA, MBBS, MRCP, PhD
University College London Great Ormond Street Institute of Child Health

Co-Leader
Louis Chesler, MD, PhD, FRCPCH
The Institute of Cancer Research

Team Co-Leader
Paul M. Sondel, MD, PhD
University of Wisconsin and UW Carbone Cancer Center

Principal Investigator
Laura Donovan, PhD
University College London Great Ormond Street Institute of Child Health

Principal Investigator
Darren Hargrave, MD, FRCPCH, MRCP
University College London Great Ormond Street Institute of Child Health

Investigator
Chiara Gorrini, PhD
The Institute of Cancer Research

Investigator
Evon Poon, PhD
The Institute of Cancer Research

Young Investigator
Marta Barisa, PhD
University College London Great Ormond Street Institute of Child Health

Young Investigator
Benjamin Draper, PhD
University College London Great Ormond Street Institute of Child Health

Young Investigator
Amy K. Erbe, PhD
University of Wisconsin and UW Carbone Cancer Center

Young Investigator
Alaide Morcavallo, PhD
The Institute of Cancer Research

Young Investigator
Sophie Munnings-Tomes, PhD
University College London Great Ormond Street Institute of Child Health

Young Investigator
Lizzie Tucker, PhD
The Institute of Cancer Research

Young Investigator
Lauren K. Zebertavage, PhD
University of Wisconsin and UW Carbone Cancer Center

Project Manager
Leanne Partington, EngD, MRes, BSc
University College London

Patient Advocate
Parker Moss

Patient Advocate
Lori R. Schultz
UW Health American Family Children’s Hospital

“TBD”

John Anderson, BA, MBBS, MRCP, PHD
University College London Great Ormond Street Institute of Child Health

TEAM PROGRESS UPDATES

Stand Up To Cancer’s research projects are designed to foster collaborative, swift translational research. The hallmarks of these efforts include rigorous application and selection procedures, sufficient funding to allow scientists to focus on the objectives of the grant, and reviews by senior scientists every six months. These reviews help the investigators capitalize on the latest findings, address potential roadblocks, and collaboratively evolve as the science requires. For the SU2C Gastric Cancer Interception Research Team, please click on the link below to see summaries of their research results so far.

TEAM PROGRESS UPDATES

PUBLICATIONS

This team started its work in January 2020. Links to publications will be posted when they are available.

CLINICAL TRIALS REFERRALS

Cancer clinical trials allow researchers to study innovative and potentially life-saving new treatments. The goal is to find treatments that are better than what’s currently available; in fact, the therapies offered to today’s cancer patients were almost all studied and made possible by people participating in clinical trials. But many cancer clinical trials aren’t completed because not enough people take part.

At StandUpToCancer.org/ClinicalTrials, you’ll find information and answers to common questions about clinical trials. Learn more and talk to your doctor to see if a clinical trial may be the best choice for you.

You can also connect with EmergingMed, a free and confidential clinical trial matching service that provides access to a vast database to help you identify the clinical trials that might be right for you or your loved one.

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